I ran into the same issue as well on ESXi 5.0 U2 + Redhat 6.x. RH 5.x works just fine, but RH6.x just stinks. VMware is aware of this. in the mean time here is the solution (the vmware KB on LRO is slightly off).
or this:
esxcli system settings advanced set --int-value 0 -o /Net/VmxnetSwLROSL
esxcli system settings advanced set --int-value 0 -o /Net/Vmxnet3SwLRO
esxcli system settings advanced set --int-value 0 -o /Net/Vmxnet3HwLRO
esxcli system settings advanced set --int-value 0 -o /Net/Vmxnet2SwLRO
esxcli system settings advanced set --int-value 0 -o /Net/Vmxnet2HwLRO
Hope this ends the misery for all!